Apone F, Tito A, Arciello S, Carotenuto G and Colucci MG.
Plant tissue cultures as sources of ingredients for skin care applications.
Annual Plant Reviews 2020, 3: 135-150.

Tito A, Minale M, Riccio S, Grieco F, Colucci MG, Apone F.
A Triticum vulgare extract exhibits regenerating activity during the wound healing process.
Clin Cosm & Invest Dermatol 2020, 13: 21-30.

Tito A, Zappelli C, Angelillo M, Colucci MG and Apone F.
A new ingredient from Rosa rugosa tissue cultures delays skin aging by promoting mitochondrial functions.
Personal Care Europe 2020, April 131-137.


Tito A, Carola A, Bertelli G, Rando P, Nohynek L, Oksman-Caldentey KM, Rischer H, Zappelli C, Colucci MG, Apone F.
A Rubus arcticus derived ingredient stimulates immune defence and reduces inflammation in skin cells by promoting microbiota balance.
The Proceedings of the 25th IFSCC Conference 2019, Milan.

Bimonte M., Carola A., Barbulova A., Zappelli C., Angelillo M., Cucchiara M., Apone F. and Colucci G.
Aubergine mutes TRPV1 and boosts TRPV-3 and TRPV-4 to reinforce and comfort skin (2019).
Cosmetics & Toiletries, 134, n. 9, 50-61.

Palmieri G., Arciello S., Bimonte M., Carola A., Tito A., Gogliettino M., Cocca E., Fusco C., Balestrieri M., Colucci M.G., Apone F.
The extraordinary resistance to UV radiations of a manganese Superoxide Dismutase of Deinococcus radiodurans offers promising potentialities in skin care applications.
J Biotechnol. 2019, 302: 101-111.

Apone, A. Barbulova, M.G. Colucci.
Plant and Microalgae Derived Peptides Are Advantageously Employed as Bioactive Compounds in Cosmetics. 
Front. In Plant Sci., 12 June 2019 doi: 10.3389/fpls.2019.00756.

Tito, A. Barbulova, C. Zappelli, M. Leone, M. Ruvo, F.A. Mercurio, A. Chambery, R. Russo, M. G. Colucci & F. Apone.
The Growth Differentiation Factor 11 is involved in skin fibroblast ageing and is induced by a preparation of peptides and sugars derived from plant cell cultures. Mol Biotechnol. 2019 Mar;61(3):209-220.


Guerriero G, Berni R, Muñoz-Sanchez JA, Apone F, Abdel-Salam EM, Qahtan AA, Alatar AA, Cantini C, Cai G, Hausman JF, Siddiqui KS, Hernández-Sotomayor SMT, Faisal M. (2018).
Production of Plant Secondary Metabolites: Examples, Tips and Suggestions for Biotechnologists.
Genes (Basel). 2018 Jun 20; 9(6).

M. Bimonte, A. Carola, A. Tito, A. Barbulova, A. De Lucia, F. Del Piaz, F. Apone & G. Colucci.
Plant cell cultures of Daphne odora produce compounds that help fighting cold stress in the skin.
Cosmetics & Toiletries, 133, n.1, 34-51.

A. De Lucia, C. Zappelli, M. Angelillo, A. L. Langellotti, V. Fogliano, M. Cucchiara, G. M. Colucci, F. Apone.
A novel biotechnological active ingredient, derived from the microalga Spirulina, increases hydration and reduces osmotic stress in skin cells.

H&PC Today – Household and Personal Care Today – vol. 13(4) July/August 2018.

I. D’Antuono, A. Carola, LM. Sena, V. Linsalata, A. Cardinali, AF. Logrieco, MG. Colucci and F. Apone.
Artichoke polyphenols produce skin anti-age effects by improving endothelial cell integrity and functionality.
Molecules 2018, 23, 2729; doi:10.3390/molecules23112729.

F. Apone, C. Zappelli, M. Angelillo & MG. Colucci.
Biotechnology research to obtain safe, effective and sustainable ingredients for Cosmetics (in polish).
Chem & Business, 4/2018: 76-81.


A. Sandomenico, V. Severino, F Apone, A. De Lucia, A. Caporale, N. Dotia, A. Russo, R. Russo, C. Rega, T. Del Giacco, L. Falcicgno, M. Ruvo, A. Chambery.
Trifluoroacetylated tyrosine-rich D-tetrapeptides have potentantioxidant activity.
Peptides, 89: 50–59.

F Apone, A Barbulova, C Zappelli, G Colucci.
Green biotechnology in cosmetics: using plant cell cultures as sources of active ingredients.
HPC Today, vol. 12 (3), May/June 2017.

LM Sena, C Zappelli, F Apone, A Barbulova, A Tito, A Leone, T Oliviero, R Ferracane, V Fogliano, G Colucci.
Brassica rapa hairy root extracts promote skin depigmentation by modulating melanin production and distribution.
J Cosmet Dermatol.1–12.

Squillaci G, Apone F, Sena LM, Carola A, Tito A, Bimonte M, De Lucia A, Colucci G, LA Cara F, Morena A.
Chestnut (Castanea sativa Mill.) industrial wastes as a valued bioresource for the production of active ingredients.
Process Biochemistry,

O. DI Martino, A. Tito, A. De Lucia, A. Cimmino, F. Cicotti, F. Apone, G. Colucci and V. Calabrò.
Hibiscus syriacus Extract from an Established Cell Culture Stimulates Skin Wound Healing.
BioMed Res Inter, Article ID 7932019, 9 pages,


G. Imparato, C. Casale, S. Scaramella, F. Urciuolo, M. Bimonte, F. Apone, G. Colucci and PA. Netti.
A novel engineered dermis for in vitro photodamage research.
J Tissue Eng Regen Med. 2016 Feb 8.

M. Bimonte, A. De Lucia, A. Carola, A. Tito, S. Buono, A. L. Langellotti, V. Fogliano, G. Colucci and Fabio Apone.
Galdieria sulphuraria Relieves Oily and Seborrheic Skin By Inhibiting the 5-α Reductase Expression in Skin Cells and Reducing Sebum Production In Vivo.

Trichology and Cosmetology. Volume 1, tissue 1.

A. Rogato, VT. Valkov, LM. Alves, F. Apone, G.Colucci, M. Chiurazzi.
Down-regulated Lotus japonicus GCR1 plants exhibit nodulation signalling pathways alteration.
Plant Sci., 247: 71-82.

C. Zappelli, A. Barbulova, F. Apone, G. Colucci.
Effective Active ingredients obtained through Biotechnology.
Cosmetics, 3, 39.

C Zappelli, F. Ciccotti, A. Tito, A. Carola, A. De Lucia, L. Sena, A. Tortora, M. Bimonte, M. Cucchiara, F. Apone, G. Colucci.
Perking Up Skin: Green Coffee Promotes Barrier Recovery, Turn Over and Lightening.
Online publication, October 18.


A. Barbulova, F. Apone & G. Colucci.
New Trends in Cosmetics: By-Products of Plant Origin and Their Potential Use as Cosmetic Active Ingredients.
Cosmetics, 2, 82-92.

A. Tito, M. Bimonte, A. Carola, A. De Lucia, A. Barbulova, A.Tortora, G. Colucci & F. Apone.
An oil-soluble extract of Rubus idaeus cells enhances hydration and water homeostasis in skin cells.

Int. J. Cosmet. Sci., 2015 May 4. doi: 10.1111/ics.12236.


Barbulova A., Apone F. & Colucci G.
Plant Cell Cultures as Source of Cosmetic Active Ingredients.

Cosmetics, 1, 94-104.A.

Apone F., Ruggiero A., Tortora A., Tito A., Grimaldi M.R., Arciello S., Andrenacci D., Di Lelio I. & Colucci G.
Targeting the diuretic hormone receptor to control the cotton leafworm, Spodoptera littoralis.

Journal of Insect Science, Vol. 14, 87, 1-16.

M. Bimonte, A. Tito, A. Carola, A. Barbulova, J. Hill, M. Cucchiara, F. Apone & G Colucci.
Dolichos cell culture extract for protection against UV damage.
Cosmetics & Toiletries, 129, 46-56.


Tortora A., Arciello S., Colucci G., Apone F.
Identification of Novel Compounds or Mixtures, Activating Common Defense Responses to Abiotic Stress both in Plants and Mammalian Skin Cells.

Advances in Medicine and Biology, vol. 49, pp. 47-67.

Buono S., Langellotti A., Martello A., Bimonte M., Tito A., Carola A., Apone F., Colucci G., Fogliano V.
Biological activities of dermatological interest by the water extract of the microalga Botryococcus braunii.

Arch Dermatol Res., 304 (9): 755-64.

Carola A, Tito A, Bimonte M, Mustilli AC, Cucchiara M, Monoli I, Hill J, Apone F, Colucci G.
Liposoluble extracts of Vitis vinifera grape marc and cell cultures with synergistic anti-ageing effects.
HPC Today, vol. 7 nr.3 July/September 2012.


Quintavalle C., Brenca M., De Micco F., Fiore D., Romano S., Romano M.F., Apone F., Bianco A., Zabatta M.A., Troncone G., Briguori C., Condorelli G.
In vivo and in vitro assessment of pathways involved in contrast media-induced renal cells apoptosis.

Cell Death Dis., May 12; 2: e 155.

Tito A., Carola A., Bimonte M., Barbulova A., Arciello S., De Laurentiis F., Monoli I., Hill J., Gibertoni S., Colucci G. & Apone F.
A tomato stem cell extract, containing antioxidant compounds and metal chelating factors, protects skin cells from heavy metal induced damages.

Int. J. Cosmet. Sci., 33(6): 543-552.

Bimonte M, Tito A, Carola A, Barbulova A, Monoli I, Cucchiara M, Hill J, Colucci G & Apone F.
A new active extract obtained from Coffea bengalensis stem cells acts on different skin cell types attenuating signs of ageing. Cosmetics & Toiletries, September 2011, vol. 126 (9): 644-650.


Barbulova A, Tito A, Carola A, Bimonte M, De Laurentiis F, D’ambrosio P, Apone F and Colucci G.
Raspberry Stem Cell Extract to Protect Skin from Inflammation and Oxidative Stress.
Cosmetics & Toiletries, 125(7): 38-47.


Apone F., Tito A., Carola A., Arciello S., Tortora A., Filippini L., Monoli I., Cucchiara M., Gibertoni S., Chrispeels M.J., Colucci G.
A mixture of peptides and sugars derived from plant cell walls increases plant defense responses to stress and attenuates ageing- associated molecular changes in cultured skin cells.

J Biotechnol., 145(4): 367-376.


Apone F., Arciello S., Colucci G., Filippini L., Portoso D.
An in-depth investigation to provide scientific bases to the biostimulant activity.

Fert. Agrorum, 1 (1): 55-63.


Apone F., Alyeshmerni N., Wiens K., Chalmers D., Chrispeels J.M. & Colucci G.
The G-protein coupled receptor GCR1 regulates DNA synthesis through activation of phosphatidylinisitol-specific phospholipase C (PI-PLC).

Plant Physiology, 133 (2): 571-9.


Colucci G., Apone F., Alyeshmerni N., Chalmers D. & Chrispeels M.
GCR1, the putative Arabidopsis G protein-coupled receptor gene is cell cycle-regulated, and its overexpression abolishes seed dormancy and shorten time to flowering.

Proc. Nat. Acad. Sci., 99 (7): 4736-4741.


Moore J.G., Fuchs C.A., Hata Y.S., Hicklin D.J., Colucci G., Chrispeels M.J., Feldman M.
A new lectin in red kidney beans called PvFRIL stimulates proliferation of NIH 3T3 cellsexpressing the Flt3 receptor.

Biochim Biophys Acta 26;1475(3):216-224.


Colucci G., Moore J.G., Feldman M. & Chrispeels M.J.
cDNA cloning of FRIL, a mannose binding lectin from Dolichos lablab, that preserves hematopoietic progenitors in suspension culture.
Proc Natl Acad Sci U S A (2):646-650.

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